Exosome method in in vitro fertilization

In recent years, innovative approaches have begun to be used to increase the chance of success in in vitro fertilization treatment. Among these, exosome therapy appears as one of the most promising treatments. Exosomes, which are small extracellular vesicles, can be used to increase the chance of success in in vitro fertilization because they have a very important role in intercellular communication.

Exosomes are structures that contain various bioactive molecules, including proteins, nucleic acids and lipids. These can influence cellular processes as well as facilitate intercellular communication. For this reason, exosomes obtained from various sources such as stem cells can make assisted reproductive techniques such as in vitro fertilization more successful by changing the basic factors affecting fertility.

What is exosome therapy?

Exosomes; They are nano-sized structures found in semen, uterine lining and follicular fluid. These are small extracellular vesicles secreted by living cells. There is research showing that exosomes have an effect on both the female and male reproductive systems, including embryo implantation.

In exosome therapy, exosomes obtained from stem cells are used for regenerative purposes. The aim of this treatment is to ensure that exosomes affect cellular behavior and regenerate and repair tissues.

Exosomes have various roles in the female reproductive system in the development of the ovaries, decreased ovarian function, polycystic ovary syndrome (PCOS), uterine diseases, endometrial receptivity and dysfunctions in the fallopian tubes. For this reason, it is thought that exosomes may have a therapeutic effect, especially in female infertility.

What is the difference between stem cell and exosome therapy?
Stem cell and exosome therapies are treatments used in regenerative medicine, and both use the body’s natural healing mechanisms to promote the repair and regeneration of tissues. However, the biological agents used in the two treatments differ.

Stem cell therapy is a treatment that uses stem cells that can transform into various cells. The therapeutic effect of stem cells stems from the fact that stem cells can transform into cells necessary for tissue repair and thus support healing.

In exosome therapy, exosomes, which are small extracellular vesicles secreted by cells, are used. Exosomes contain proteins, lipids and genetic material found in the parent cell. The therapeutic effect of exosomes stems from their role in intercellular communication and affecting the behavior of cells.

Both stem cell and exosome therapy are promising treatments in the field of regenerative medicine. Depending on the problem to be treated in in vitro fertilization, your doctor will inform you about whether stem cell or exosome therapy should be preferred and offer the best option.


All processes occurring in the female reproductive system, including pregnancy, are related to intercellular communication. Exosomes play an important role in this communication. Exosomes participate in the necessary communication between cells during and immediately after fertilization.

Exosomes are used in in vitro fertilization because they can be effective in processes such as promoting endometrial receptivity, improving ovarian function, and supporting embryo implantation. For this reason, exosome therapy can be used to increase the chance of success in in vitro fertilization.

Exosome treatment in in vitro fertilization is generally thought to have the following benefits:

Endometrial receptivity: Endometrial receptivity means that the endometrium, the inner layer of the uterus, is in a suitable condition for the implantation of the embryo. For this reason, it has an important role in the success of assisted reproductive techniques such as in vitro fertilization.

The endometrium goes through different stages as it changes throughout the menstrual cycle. It is very important to perform embryo transfer during the implantation window, which is the period when the endometrium is most receptive, in order to increase the success of in vitro fertilization.

Exosomes may play a role in promoting receptivity of the endometrium. In this way, it can help increase the chances of success in embryo implantation.

Ovarian function: The basic functions of the ovaries are to produce eggs for fertilization every month and to provide estrogen and progesterone hormones necessary for the establishment and maintenance of pregnancy. Although some women with infertility problems have problems with their ovarian functions, it is possible for ovulation to occur depending on age.

For in vitro fertilization to be successful, the ovaries must produce more than one egg during the cycle. In this way, more than one embryo is formed and the selected embryo or embryos can be transferred to the uterus.

It is thought that exosomes may affect ovarian function and the quality and development of eggs. For this reason, exosome therapy can be used to increase the chance of success in in vitro fertilization.

Exosome treatment in in vitro fertilization is generally carried out in a similar process to other regenerative treatments. Exosome therapy, a minimally invasive procedure, may be recommended for some patients to increase the chances of pregnancy through in vitro fertilization.

Although the way exosome treatment is applied in in vitro fertilization may vary depending on the clinic, the steps followed are generally as follows:

  • Exosomes are first obtained and isolated from stem cells.
  • Isolated exosomes are checked for purity and quality.
  • Exosomes are prepared to be converted into a form suitable for administration. Exosomes can be administered intravenously or by injection, depending on the area to be treated.
  • The patient is closely monitored to evaluate the effects of exosome treatment in in vitro fertilization. For this, ultrasound, blood test and other procedures used in in vitro fertilization can be used.

Since the purpose of use of exosome therapy in in vitro fertilization may vary, you should discuss the treatment in detail with your doctor. In this way, you can learn what exosome therapy can do in your case and eliminate all question marks by asking your doctor the questions you have in mind.

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